Input data | Minimal example | Outcome | Customising "clinically relevant change" | Baseline scheme | Additional options | Multiple events | Event confirmation | Sustained CDW or CDI | Relapse-based classification of CDW events | Relapse-associated worsening (RAW) | Progression independent of relapse activity (PIRA) | MSprog() outputs | What to include in results | Printing progress info | Time to disability milestone | References
Package: msprog 1.0.1
msprog: Reproducible Assessment of Disability Course in Multiple Sclerosis
Analyse disability course in multiple sclerosis (MS) from longitudinal data. The package provides a flexible framework for identifying disability events under user-specified criteria, allowing adaptation to different study designs and endpoints. Tools are included to facilitate transparent and reproducible reporting of the settings used in the analysis. For consensus-based recommendations on endpoint calculation and use of the package, see Montobbio et al. (2026) <doi:10.1177/13524585261478492>. For the original description of the computational framework and illustrative applications, see Montobbio et al. (2024) <doi:10.1177/13524585241243157>.
Authors:
msprog_1.0.1.tar.gz
msprog_1.0.1.zip(r-4.7-any)msprog_1.0.1.zip(r-4.6-any)msprog_1.0.1.zip(r-4.5-any)
msprog_1.0.1.tgz(r-4.6-any)msprog_1.0.1.tgz(r-4.5-any)
msprog_1.0.1.tar.gz(r-4.7-any)msprog_1.0.1.tar.gz(r-4.6-any)
msprog_1.0.1.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION
card.svg |card.png
msprog/json (API)
| # Install 'msprog' in R: |
| install.packages('msprog', repos = c('https://noemimontobbio.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/noemimontobbio/msprog/issues
Datasets:
- toydata_relapses - Synthetic Relapse Data
- toydata_visits - Synthetic Longitudinal EDSS and SDMT Data
Last updated from:82e5de70a2. Checks:9 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel | OK | 159 | ||
| source / vignettes | OK | 200 | ||
| linux-release | OK | 118 | ||
| macos-release | OK | 147 | ||
| macos-oldrel | OK | 183 | ||
| windows-devel | OK | 64 | ||
| windows-release | OK | 77 | ||
| windows-oldrel | OK | 59 | ||
| wasm-release | OK | 90 |
Exports:compute_deltais_eventMSprogrelapse_indep_from_boundsvalue_milestone
Dependencies:clidplyrgenericsgluelifecyclemagrittrpillarpkgconfigR6rlangtibbletidyselectutf8vctrswithr
Analysing disability course in MS
Last update: 2026-09-03
Started: 2023-06-22
Assessing progression independent of relapse activity (PIRA) in MS
Defining PIRA | Detecting PIRA | References
Last update: 2026-09-03
Started: 2023-12-14
Time to event
Time to first disability worsening event | Time to disability milestone | Multiple events
Last update: 2026-05-26
Started: 2024-11-04
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Default minimum clinically meaningful shift for different scales. | compute_delta |
| Compare value to reference. | is_event |
| Assess multiple sclerosis disability course from longitudinal data. | MSprog |
| Textual description of criteria used to assess disability course. | print.MSprogOutput |
| Define relapse-free intervals for PIRA definition. | relapse_indep_from_bounds |
| Synthetic Relapse Data | toydata_relapses |
| Synthetic Longitudinal EDSS and SDMT Data | toydata_visits |
| Time to disability milestone. | value_milestone |